Complex Lipids function, definition, types & structure, Phospholipids & Glycolipids

Complex lipids are widely distributed in plants, bacteria, and animals. They are the major constituents of cell membranes but they are found also in circulating fluids. Complex lipids can be classified into four main groups: Lipids with the phosphate residue, one glycerol, or the aminoalcohol or fatty alcohol, and with one or two fatty chains.

Complex lipids

Complex lipids contain frequently three or more chemical identities (i.e. glycerol, fatty acids and sugar, one long chain base, one nucleoside, one fatty acid, and one phosphate group…) and they have polar properties, and some complex lipids contain only two components but including a sugar moiety.

1- Phospholipids

They are membrane components, amphipathic, ionic compounds, there are two classes of phospholipids, those that have glycerol as a backbone (Glycerophospholipids) and those that have sphingosine as a backbone (sphingophospholipids), both are considered as a constant element of fat.

GlygeroRhospholipids

The precursor compound of glycerophospholipids is the phosphoric ester of glycerol (glycerol-3-phosphate). this compound has an asymmetric carbon atom and can exist either in D form or L form, it was found that the L-isomer of glycerol phosphate is found in the natural phosphoglycerols (phosphoglycerides).

Complex Lipids

Complex Lipids

L-Phosphoacylglycerol (L-phosphoglycerides)

The fatty acids present in phosphoglycerides are one mostly saturated in the 1st position of glycerol, the second is an unsaturated fatty acid, both are high fatty acids, phospholipids because they have phosphoryl bases as polar hydrophilic heads (ionizable heads) in addition to their hydrocarbon non-polar hydrophobic tail are considered (amphipathic).

Types of Glycerophosppholipics

1- Phosphatidic acid is the simplest form of phosphoglycerols and it is the precursor of the other members of this group, it is present mainly as an intermediate compound during the synthesis of phosphoglycerols and triacylglycerol, it occurs in very small amounts in the cell, it has no base.

2- Lecithin (phosphatidyl choline) is the most abundant phosphoglyceride in plants and animals, the base here choline, It is present in the animal’s cell membrane.

Dipalmitoyl lecithin: in this phospholipid position 4,2 of glycerol are occupied by palmitate, this phospholipid is the major lipid components of lung surfactants (The extracellular fluid lining the alveoli), surfactants serve to decrease the surface tension of the fluid layer, therefore, prevent alveolar collapse, its absence from the lungs of premature infants causes respiratory distress syndrome.

3- Cephalin (phosphatidyl ethanolamine) is another abundant phosphoglycerols (phosphoglycerides) which is also found in the animal cell membrane, the base is ethanolamine, there are 3 and 2 cephalin, cephalin is one of the important blood clotting factors.

4- Phosphatidyl serine is cephalin- like and present in many tissues, the base is the amino acid serine.

5- Lipositol (phosphatidyl inositol): The polar head here is the cyclic hexose sugar alcohol inositol (myoinositol), two or three moles of phosphoric acid may be present in inositol phosphatide, an inositol phosphatide containing 3 moles of phosphoric acid (1, 4, 5) is present in the brain and muscles.

Sphingophospholipids

This group of phospholipids contain sphingosine instead of glycerol, a higher fatty acid as lignoceric acid, phosphoric acid, and a base, they are important membrane components both in plants and animal cells, they are present especially in large amounts in the brain and myelin of nerve tissues.

The amino group of sphingosine is connected by an amide linkage to a long chain saturated or monounsaturated fatty acid, the resulting compound is called Ceramide, it is the characteristic parent structure of all sphingolipids, the most abundant sphingophospholipids in tissues of animals are sphingomyelins, they contain a phosphoryl choline as their polar head group.

2- Glycolipids (Glycosphingolipids)

Glycolipids are widely distributed in every tissue of the body, particularly in nervous tissue such as the brain, they occur also in the outer leaflet of the plasma membrane having a role in cell communication.

Glycolipids are classified into:

1- Neutral (cerebrosides), according to the monosaccharide bound to the ceramide they are:

  • Galactocerbroside
  • Glucocerebroside

2- Acidic:

  • Sulfatides (Galactocerbroside Sulfate).
  • Gangliosides (Glucocerebroside to which one or more sialic acids are added)

Classification of lipids, Simple lipids & fatty acids, Triacylglycerols & importance of true fats

Types of Derived lipids, Steroids, Animal sterols, Plant sterols & bile acids

Carbohydrates, Polysaccharides, Proteoglycans, Glycoproteins & Glycosaminoglycans

Carbohydrates importance, Types of Isomerism, Monosaccharides & Disaccharides

Connective tissue cells types, function & structure, Resident cells & Transient cells

Integumentary system, Skin importance, layers, types & function

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